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IWP-2 is an inhibitor of Wnt processing and secretion with an IC50 of 27 nM. IWP-2 targets the membrane-bound O-acyltransferase porcupine (Porcn) and thus preventing a crucial Wnt ligand palmitoylation. IWP-2 is also an ATP-competitive CK1δ inhibitor with an IC50 of 40 nM for the gatekeeper mutant M82FCK1δ.
|Research Field||Cancer, Stem Cell/Wnt, Cell Cycle/DNA Damage|
|Format||Solubility: DMF : 12.5 mg/mL (26.79 mM; ultrasonic and warming and heat to 60°C) ; DMSO : 2 mg/mL (4.29 mM; Need ultr...|
|Grade||Clinical information: No Development Reported|
|Storage Conditions||Powder -20°C 3 years, 4°C 2 years; In solvent -80°C 6 months, -20°C 1 month|
|Tech. Data Sheet||View datasheet|
|Link To Supplier||http://www.medchemexpress.com|
|Shipping Details||Room temperature|
|Material Safety Data Sheet||Download PDF|