BMS-984923


Catalog Number Pack Size List Price* Quantity
HY-122559-10MG 10 mg   Inquire
HY-122559-5MG 5 mg   Inquire

* CHF, excl. 7.7% VAT and shipping costs


Product Description

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BMS-984923, a potent mGluR5 silent allosteric modulator (SAM), with exquisite binding affinity (Ki = 0.6 nM), exhibits good oral bioavailability and BBB penetration. BMS-984923 potently inhibits the PrPC-mGluR5 interaction and prevents pathological Aβo signaling without affecting physiological glutamate signaling.

Category Biochemicals
Supplier MedChem Express
Regulatory Status RUO
Research Field Neurological Disease, GPCR/G Protein, Neuronal Signaling
Format Solubility: DMSO : 100 mg/mL (266.79 mM; Need ultrasonic)
Grade Clinical information: Phase 1
Purity 99.94%
Molecular Formula C22H15ClN2O2
Molecular Weight 374.82
CAS-Number 1375752-78-5
Storage Conditions Powder -20°C 3 years; In solvent -80°C 6 months, -20°C 1 month
Tech. Data Sheet View datasheet
Link To Supplier http://www.medchemexpress.com
Shipping Details Room temperature
Material Safety Data Sheet Download PDF