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BMS-984923, a potent mGluR5 silent allosteric modulator (SAM), with exquisite binding affinity (Ki = 0.6 nM), exhibits good oral bioavailability and BBB penetration. BMS-984923 potently inhibits the PrPC-mGluR5 interaction and prevents pathological Aβo signaling without affecting physiological glutamate signaling.
|Research Field||Neurological Disease, GPCR/G Protein, Neuronal Signaling|
|Format||Solubility: DMSO : 100 mg/mL (266.79 mM; Need ultrasonic)|
|Grade||Clinical information: Phase 1|
|Storage Conditions||Powder -20°C 3 years; In solvent -80°C 6 months, -20°C 1 month|
|Tech. Data Sheet||View datasheet|
|Link To Supplier||http://www.medchemexpress.com|
|Shipping Details||Room temperature|
|Material Safety Data Sheet||Download PDF|