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SK-575 is a highly potent and specific proteolysis-targeting chimera (PROTAC) degrader of PARP1, with an IC50 of 2.30 nM. SK-575 potently inhibits the growth of cancer cells bearing BRCA1/2 mutations.
|Research Field||Cancer, PROTAC, Cell Cycle/DNA Damage, Epigenetics|
|Format||Solubility: DMSO : 100 mg/mL (114.03 mM; Need ultrasonic)|
|Grade||Clinical information: No Development Reported|
|Storage Conditions||-20°C, sealed storage, away from moisture and light; In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light)|
|Tech. Data Sheet||View datasheet|
|Link To Supplier||http://www.medchemexpress.com|
|Shipping Details||Room temperature|
|Material Safety Data Sheet||Download PDF|