Y-27632 dihydrochloride


Catalog Number Pack Size List Price* Promo Price* Quantity
HY-10583-1ML 10 mM * 1 mL 67,00 50,30 Add
HY-10583-10MG 10 mg 85,00 63,80 Add
HY-10583-50MG 50 mg 256,00 192,00 Add
HY-10583-100MG 100 mg 423,00 317,30 Add
HY-10583-200MG 200 mg 661,00 495,80 Add
HY-10583-500MG 500 mg 1'271,00 953,30 Add
HY-10583-1G 1 g 1'819,00 1'364,30 Add
HY-10583-2G 2 g 2'918,00 2'188,50 Add
HY-10583-S-1ST Sample   Inquire

* CHF, excl. 7.7% VAT and shipping costs


Product Description

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Y-27632 dihydrochloride is an orally active, ATP-competitive inhibitor of ROCK-I and ROCK-II, with Kis of 220 and 300 nM, respectively. Y-27632 dihydrochloride attenuates Doxorubicin-induced apoptosis of human cardiac stem cells. Y-27632 also suppresses dissociation-induced apoptosis of murine prostate stem/progenitor cells. Y-27632 dihydrochloride primes human induced pluripotent stem cells (hIPSCs) to selectively differentiate towards mesendodermal lineage via epithelial-mesenchymal transition-like modulation.

Category Biochemicals
Supplier MedChem Express
Regulatory Status RUO
Research Field Cancer, Cell Cycle/DNA Damage, Cytoskeleton, Stem Cell/Wnt, TGF-beta/Smad, Apoptosis
Format Solubility: H2O : 100 mg/mL (312.25 mM; Need ultrasonic) ; DMSO : 33.33 mg/mL (104.07 mM; Need ultrasonic)
Grade Clinical information: No Development Reported
Purity 95%
Molecular Formula C14H23Cl2N3O
Molecular Weight 320.26
CAS-Number 129830-38-2
Storage Conditions 4°C, sealed storage, away from moisture; In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
Tech. Data Sheet View datasheet
Link To Supplier http://www.medchemexpress.com
Shipping Details Room temperature
Material Safety Data Sheet Download PDF