|Catalog Number||Pack Size||List Price*||Promo Price*||Quantity|
|HY-10583-1ML||10 mM * 1 mL||67,00||50,30||Add|
* CHF, excl. 7.7% VAT and shipping costs
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Y-27632 dihydrochloride is an orally active, ATP-competitive inhibitor of ROCK-I and ROCK-II, with Kis of 220 and 300 nM, respectively. Y-27632 dihydrochloride attenuates Doxorubicin-induced apoptosis of human cardiac stem cells. Y-27632 also suppresses dissociation-induced apoptosis of murine prostate stem/progenitor cells. Y-27632 dihydrochloride primes human induced pluripotent stem cells (hIPSCs) to selectively differentiate towards mesendodermal lineage via epithelial-mesenchymal transition-like modulation.
|Research Field||Cancer, Cell Cycle/DNA Damage, Cytoskeleton, Stem Cell/Wnt, TGF-beta/Smad, Apoptosis|
|Format||Solubility: H2O : 100 mg/mL (312.25 mM; Need ultrasonic) ; DMSO : 33.33 mg/mL (104.07 mM; Need ultrasonic)|
|Grade||Clinical information: No Development Reported|
|Storage Conditions||4°C, sealed storage, away from moisture; In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)|
|Tech. Data Sheet||View datasheet|
|Link To Supplier||http://www.medchemexpress.com|
|Shipping Details||Room temperature|
|Material Safety Data Sheet||Download PDF|