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Coleonol; Colforsin; HL 362
Forskolin (Coleonol) is a potent adenylate cyclase activator with an IC50 of 41 nM and an EC50 of 0.5 μM for type I adenylyl cyclase. Forskolin is also an inducer of intracellular cAMP formation. Forskolin induces differentiation of various cell types and activates pregnane X receptor (PXR) and FXR. Forskolin exerts a inotropic effect on the heart, and has platelet antiaggregatory and antihypertensive actions. Forskolin also induces autophagy.
|Research Field||Cancer, Endocrinology, Metabolic Disease, Inflammation/Immunology, Autophagy,GPCR/G Protein,Metabolic Enzyme/Protease|
|Format||Solubility: DMSO : 100 mg/mL (ultrasonic)|
|Grade||Clinical information: No Development Reported|
|Storage Conditions||4°C (Powder, protect from light)|
|Tech. Data Sheet||View datasheet|
|Link To Supplier||http://www.medchemexpress.com|
|Shipping Details||Room Temperature|
|Material Safety Data Sheet||Download PDF|