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35% discount on MedChem product orders above CHF 1'000 !
- 1st November - 31st December 2023
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DAPT (GSI-IX) is a potent and orally active γ-secretase inhibitor with IC50s of 115 nM and 200 nM for total amyloid-β (Aβ) and Aβ42, respectively. DAPT inhibits the activation of Notch 1 signaling and induces cell differentiation. DAPT also induces autophagy and apoptosis. DAPT has neuroprotection activity and has the potential for autoimmune and lymphoproliferative diseases, degenerative disease and cancers treatment.
|Research Field||Cancer, Inflammation/Immunology, Neurological Disease, Apoptosis,Autophagy,Neuronal Signaling,Stem Cell/Wnt|
|Format||Solubility: DMSO : 62.5 mg/mL (ultrasonic)|
|Grade||Clinical information: No Development Reported|
|Storage Conditions||-20°C, 3 years; 4°C, 2 years (Powder)|
|Tech. Data Sheet||View datasheet|
|Link To Supplier||http://www.medchemexpress.com|
|Shipping Details||Room Temperature|
|Material Safety Data Sheet||Download PDF|