DAPT


Catalog Number Pack Size List Price* Quantity
HY-13027-5MG 5 mg 98,00 Add
HY-13027-1ML 10mM/1mL 107,00 Add
HY-13027-10MG 10 mg 159,00 Add
HY-13027-50MG 50 mg 463,00 Add
HY-13027-S-1ST Sample   Inquire

* CHF, excl. 8.1% VAT and shipping costs


Product Description

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DAPT (GSI-IX) is a potent and orally active γ-secretase inhibitor with IC50s of 115 nM and 200 nM for total amyloid-β (Aβ) and Aβ42, respectively. DAPT inhibits the activation of Notch 1 signaling and induces cell differentiation. DAPT also induces autophagy and apoptosis. DAPT has neuroprotection activity and has the potential for autoimmune and lymphoproliferative diseases, degenerative disease and cancers treatment[1][2].

Category Biochemicals
Supplier MedChem Express
Regulatory Status RUO
Research Field Cancer, Inflammation/Immunology, Neurological Disease
Format Solubility: DMSO : 62.5 mg/mL (ultrasonic)
Grade Clinical information: No Development Reported
Purity 99.91%
Molecular Formula C23H26F2N2O4
Molecular Weight 432.46
CAS-Number 208255-80-5
Storage Conditions -20°C, 3 years; 4°C, 2 years (Powder)
Tech. Data Sheet View datasheet
Link To Supplier http://www.medchemexpress.com
Shipping Details Room Temperature
Material Safety Data Sheet Download PDF