Sorafenib


Catalog Number Pack Size List Price* Quantity
HY-10201-100MG 100 mg 89,00 Add
HY-10201-1ML 10mM/1mL 97,00 Add
HY-10201-1G 1 g 173,00 Add
HY-10201-S-1ST Sample   Inquire

* CHF, excl. 8.1% VAT and shipping costs


Product Description

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Sorafenib (Bay 43-9006) is a potent and orally active Raf inhibitor with IC50s of 6 nM and 20 nM for Raf-1 and B-Raf, respectively. Sorafenib is a multikinase inhibitor with IC50s of 90 nM, 15 nM, 20 nM, 57 nM and 58 nM for VEGFR2, VEGFR3, PDGFRβ, FLT3 and c-Kit, respectively. Sorafenib induces autophagy and apoptosis. Sorafenib has anti-tumor activity. Sorafenib is a ferroptosis activator[1].

Category Biochemicals
Supplier MedChem Express
Regulatory Status RUO
Research Field Cancer, Apoptosis,Autophagy,MAPK/ERK Pathway,Protein Tyrosine Kinase/RTK
Format Solubility: DMSO : ≥ 45 mg/mL
Grade Clinical information: Launched
Purity 99.92%
Molecular Formula C21H16ClF3N4O3
Molecular Weight 464.83
CAS-Number 284461-73-0
Storage Conditions -20°C, 3 years; 4°C, 2 years (Powder)
Tech. Data Sheet View datasheet
Link To Supplier http://www.medchemexpress.com
Shipping Details Room Temperature
Material Safety Data Sheet Download PDF