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LY294002 is a broad-spectrum inhibitor of PI3K with IC50s of 0.5, 0.57, and 0.97 μM for PI3Kα, PI3Kδ and PI3Kβ, respectively. LY294002 also inhibits CK2 with an IC50 of 98 nM. LY294002 is a competitive DNA-PK inhibitor that binds reversibly to the kinase domain of DNA-PK with an IC50 of 1.4 μM. LY294002 is an apoptosis activator.
|Research Field||Cancer, Infection, Apoptosis,Autophagy,Cell Cycle/DNA Damage,PI3K/Akt/mTOR,Stem Cell/Wnt|
|Format||Solubility: DMSO : 50 mg/mL (ultrasonic);Ethanol : 50 mg/mL (ultrasonic)|
|Grade||Clinical information: No Development Reported|
|Storage Conditions||-20°C, 3 years; 4°C, 2 years (Powder)|
|Tech. Data Sheet||View datasheet|
|Link To Supplier||http://www.medchemexpress.com|
|Shipping Details||Room Temperature|
|Material Safety Data Sheet||Download PDF|