ONX-0914 (PR-957)
Catalog Number | Pack Size | List Price* | Quantity | |
---|---|---|---|---|
F1410-5MG | 5 mg | 142,00 | Add | |
F1411-25MG | 25 mg | 420,00 | Add |
* CHF, excl. 8.1% VAT and shipping costs
Product Description
Please inquire a quote for two or more UBPBio products
ONX-0914, also known as PR-957, is a potent inhibitor of the immunoproteasome with minimal cross-reactivity for the constitutive proteasome. ONX-0914 selectively inhibits low-molecular mass polypeptide-7 (LMP7), the subunit specific for the immunoproteasome that catalyzes the chymotyrpsion-like activity, with an IC50 < 100 nM. Cell culture and animal studies have shown that ONX-0914 blocks the production of proinflammatory cytokines including interleukin-6 and 17, indicating that it has potential uses in the treatment of some autoimmune diseases such as rheumatoid arthritis, inflammatory bowel disease and lupus. Dose: 0.1-0.5 μM for in vitro or cell couture assays; intravenous or subcutaneous administration at 2-10 mg/Kg daily for 5-7 days for animal studies.
Category | Inhibitor |
Supplier | UBPBio |
Regulatory Status | RUO |
Format | Powder; no buffer |
CAS-Number | 960374-59-8 |
Storage Conditions | -20°C |
Tech. Data Sheet | View datasheet |
Link To Supplier | http://www.ubpbio.com |
Shipping Details | Ambient temp. |
Material Safety Data Sheet | Download PDF |