TAK-243
| Catalog Number | Pack Size | List Price* | Quantity | |
|---|---|---|---|---|
| HY-100487-5MG | 5 mg | 167,00 | Add | |
| HY-100487-1ML | 10mM/1mL | 185,00 | Add | |
| HY-100487-10MG | 10 mg | 250,00 | Add | |
| HY-100487-50MG | 50 mg | 753,00 | Add | |
| HY-100487-100MG | 100 mg | 1'310,00 | Add | |
| HY-100487-S-1ST | Sample | Inquire |
* CHF, excl. 8.1% VAT and shipping costs
Product Description
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TAK-243 (MLN7243) is a first-in-class, selective ubiquitin activating enzyme, UAE (UBA1) inhibitor (IC50=1 nM), which blocks ubiquitin conjugation, disrupting monoubiquitin signaling as well as global protein ubiquitination. TAK-243 (MLN7243) induces endoplasmic reticulum (ER) stress, abrogates NF-κB pathway activation and promotes apoptosis[1][2].
| Category | Biochemicals |
| Supplier | MedChem Express |
| Regulatory Status | RUO |
| Research Field | Cancer, Apoptosis,Metabolic Enzyme/Protease,NF-κB |
| Format | Solubility: DMSO : 50 mg/mL (ultrasonic);H2O : < 0.1 mg/mL (ultrasonic) |
| Grade | Clinical information: Phase 1 |
| Purity | 98.38% |
| Molecular Formula | C19H20F3N5O5S2 |
| Molecular Weight | 519.52 |
| CAS-Number | 1450833-55-2 |
| Storage Conditions | -20°C, 3 years; 4°C, 2 years (Powder) |
| Tech. Data Sheet | View datasheet |
| Link To Supplier | http://www.medchemexpress.com |
| Shipping Details | Room Temperature |
| Material Safety Data Sheet | Download PDF |
