Fmoc-His(3-Me)-OH


Catalog Number Pack Size List Price* Quantity
HY-W111226-50MG 50 mg 128,00 Add
HY-W111226-100MG 100 mg 204,00 Add
HY-W111226-250MG 250 mg 330,00 Add

* CHF, excl. 8.1% VAT and shipping costs


Product Description

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Fmoc-His(3-Me)OH derives Histidine-associating compounds with biological activity. Fmoc-His(3-Me)OH, with Fmoc-citrulline-OH, Fmoc-His(1-Me)-OH together, forms tri-peptides and shows vasodilating effect with EC50s of 2.7-4.7 mM in 1.0 mM Phenylephrine (PE)-contracted aorta rings. Fmoc-His(3-Me)OH (resin) also makes Methyl-His-Gly-Lys (His(3-Me)-Gly-Lys), thus acts as an [Ca2+]i inhibitor. Fmoc-His(3-Me)OH methylates NAHIS02, making it unable to block the Alzheimer's Aβ channel[1][2][3].

Category Peptide
Supplier MedChem Express
Regulatory Status RUO
Research Field Cardiovascular Disease, Neuronal Signaling,s
Format Solubility: 10 mM in DMSO
Grade Clinical information: No Development Reported
Purity 98%
Molecular Formula C22H21N3O4
Molecular Weight 391.42
CAS-Number 252049-16-4
Storage Conditions -20°C, 3 years; 4°C, 2 years (Powder)
Tech. Data Sheet View datasheet
Link To Supplier http://www.medchemexpress.com
Shipping Details Room Temperature
Material Safety Data Sheet Download PDF