Anti-p53 WT Unconjugated, RUO
Catalog Number | Pack Size | List Price* | Quantity | |
---|---|---|---|---|
102201-100uG | 100 µg | 252,00 | Add | |
102203-500uG | 500 µg | 810,00 | Add | |
102201-FS | Free sample | Inquire |
* CHF, excl. 8.1% VAT and shipping costs
Product Description
p53 acts as a tumor suppressor in many tumor types; it induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator, p53 acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression. Implicated in Notch signaling cross-over. Isoform 2 enhances the transactivation activity of isoform 1 from some but not all TP53-inducible promoters. Isoform 4 suppresses transactivation activity and impairs growth suppression mediated by isoform 1. Isoform 7 inhibits isoform 1-mediated apoptosis.
Category | Antibody |
Supplier | Caprico Biotechnologies |
Regulatory Status | RUO |
Research Field | p53, cancer marker |
Host | Ms |
Clone Number | [PAB1620] |
Isotype | IgG2a,k |
Crossreactivity | Hu |
Conjugation | Unconjugated |
Storage Conditions | 2-8°C |
Link To Supplier | https://www.capricobio.com |
Shipping Details | 2-8°C |
Material Safety Data Sheet | Download PDF |