CD154 iFluor 488, RUO
Catalog Number | Pack Size | List Price* | Quantity | |
---|---|---|---|---|
1068114-25TST | 25 Test | 141,00 | Add | |
1068115-100TST | 100 Test | 292,00 | Add | |
1068116-200TST | 200 Test | 484,00 | Add | |
1068114-FS | Free sample | Inquire |
* CHF, excl. 8.1% VAT and shipping costs
Product Description
The clone 5C8, a mouse monoclonal antibody, specifically recognizes a ~30-33 kDa activation-induced human CD4+ T cells surface molecule known as CD154 or CD40 ligand (CD40L). The CD40 interacts with CD154 through T cell-B cell activating molecule, gp39, TNF cytokine related activation protein. CD154 is primarily expressed on the surface of activated CD4+ T cells but can also be expressed by platelets, mast cells, macrophages, basophils, NK cells, B cells, CD8+ T cells as well as non-hematopoietic cells including smooth muscle cells, endothelial cells, and epithelial cells. CD154 plays important roles in the pathogenesis of certain blood cancer such as the CD4+ T cells of patients with CLL fail to express surface CD154 antigen even after CD3 ligation, and proximal and distal activation events are required for the neonatal CD4+ T cells for the CD154 gene transcription to establish the normal immune system.
Category | Antibody |
Supplier | Caprico Biotechnologies |
Application | FC |
Regulatory Status | RUO |
Host | Ms |
Clone Number | [5C8] |
Isotype | IgG2a,k |
Crossreactivity | Hu |
Conjugation | iFluor™488 |
Storage Conditions | 2-8°C |
Link To Supplier | https://www.capricobio.com |
Shipping Details | 2-8°C |
Material Safety Data Sheet | Download PDF |