Nycodenz® - Iohexol [Previous 1002424]

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Product Description

Nycodenz is a non-ionic tri-iodinated derivative of benzoic acid with three aliphatic hydrophilic side chains. The systematic name of Nycodenz is 5- (N-2, 3-dihydroxypropylacetamido)-2, 4, 6-tri-iodo-N, N'-bis (2, 3 dihydroxypropyl) isophthalamide. Nycodenz has a molecular weight of 821 and a density of 2.1 g/ml. Nycodenz is non-ionic, non-toxic and is very water soluble. Stock solutions of over 80% (w/v) can be prepared. Nycodenz is also soluble in formamide and dimethyl formamide, thus it is possible to prepare non-aqueous denaturing gradients of Nycodenz. Aqueous solutions of Nycodenz have a very high water activity. Most particles will therefore be fully hydrated in solutions of Nycodenz and will band at a low density. Solutions of Nycodenz are stable to heat and may be autoclaved, stability to autoclaving is enhanced by the addition of small amounts of Tris and EDTA. Solutions of Nycodenz are very resistant to bacterial degradation and Nycodenz is not metabolized by mammalian cells.