alpha Tubulin Monoclonal Antibody (DM1A), Biotin, eBioscience™

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Product Description

Description: The monoclonal antibody DM1a recognizes the 50kDa cytoskeletal protein alpha tubulin in a variety of species (human, mouse, rat, monkey, dog, pig, bovine, goat, hamster, guinea pig, kangaroo, amphibians, sea urchin, yeast and tobacco plants). Tubulin, the major component of microtubules, is a dimeric protein consisting of an alpha and beta subunit. Tubulin is a GTP-binding protein that can be modified by phosphorylation and acetylation resulting in assembly (polymerization) or disassembly (depolymerization). The dynamic nature of microtubules is most evident in the mitotic apparatus. The DM1a antibody recognizes the C-terminal end of the alpha tubulin isoform (amino acids 426-430). Applications Reported: This DM1A antibody has been reported for use in immunocytochemistry, and immunohistochemical staining of formalin-fixed paraffin embedded tissue sections. Applications Tested: This DM1A antibody has been tested by immunofluorescent staining of paraformaldehyde fixed and permeabilized cells. This can be used at less than or equal to 10 µg/mL. It is recommeded that the antibody be titrated for optimal performance in the assay of interest. Filtration: 0.2 µm post-manufacturing filtered. Alpha Tubulin is a part of a heterodimer consisting of alpha