IL-1 beta Monoclonal Antibody (CRM57), Biotin, eBioscience™

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Product Description

Description: The CRM57 antibody reacts with human and baboon interleukin-1beta (IL-1beta). IL-1beta is a 17 kDa factor secreted primarily by monocytes. IL-1 has effects on T-helper cells, inducing IL-2 secretion and expression of IL-2 receptors. IL-1 has effects on B cells, promoting cell proliferation and immunoglobulin synthesis. Applications Reported: The CRM57 antibody has been reported for use in ELISA and ELISPOT. Applications Tested: The CRM57 antibody has been tested as the detection antibody in a sandwich ELISA for analysis of human interleukin-1 beta (IL-1 beta) in combination with the purified CRM56 (14-7018) for capture and recombinant human IL-1 beta (14-8018) as the standard. A suitable range of concentrations of this antibody for use in ELISA detection is 0.25 -1 µg/mL. A standard curve consisting of doubling dilutions of the recombinant standard over the range of 1000 pg/mL - 8 pg/mL should be included in each ELISA plate. Filtration: 0.2 µm post-manufacturing filtered. Interleukin-1 beta (IL-1 beta) is a proinflammatory cytokine expressed by monocytes, macrophages, and dendritic cells. IL-1 beta is synthesized in response to inflammatory stimuli as a 31 kDa inactive pro-form that accumulates in the cytosol. Cleavage of pro-IL-1 beta into th