STAT5 beta Monoclonal Antibody (ST5b-10G1)
| Catalog Number | Pack Size | List Price* | Quantity | |
|---|---|---|---|---|
| 135300 | 100 µg | 586,00 | Add |
* CHF, excl. 8.1% VAT and shipping costs
Product Description
The protein encoded by this gene is a member of the STAT family of transcription factors. In response to cytokines and growth factors, STAT family members are phosphorylated by the receptor associated kinases, and then form homo- or heterodimers that translocate to the cell nucleus where they act as transcription activators. This protein mediates the signal transduction triggered by various cell ligands, such as IL2, IL4, CSF1, and different growth hormones. It has been shown to be involved in diverse biological processes, such as TCR signaling, apoptosis, adult mammary gland development, and sexual dimorphism of liver gene expression. This gene was found to fuse to retinoic acid receptor-alpha (RARA) gene in a small subset of acute promyelocytic leukemias (APLL). The dysregulation of the signaling pathways mediated by this protein may be the cause of the APLL.
| Category | Antibody |
| Supplier | ThermoFisher |
| Application | ChIP, EL, ICC, IHC, IP, WB |
| Regulatory Status | RUO |
| Immunogen | A peptide corresponding to the unique carboxy-terminus of murine STAT5b coupled to a protein carrier. |
| Host | Ms |
| Clone Number | [ST5b-10G1] |
| Genebank | STAT5B |
| Isotype | IgG2a |
| Crossreactivity | Hu, Ms, Rt |
| Clonality | Mab |
| Format | Liquid; PBS; pH 7.4, with 0.1% sodium azide |
| Concentration | 0.5 mg/mL |
| Working Dilution | Immunoprecipitation (Assay-dependent), ChIP Assay (5 µg/mL), Western Blot (1:250), Immunocytochem... |
| Purity | Affinity chromatography |
| Conjugation | Unconjugated |
| Storage Conditions | -20°C |
| Disclaimer | Alternative CatNo: 13-5300 |
| Tech. Data Sheet | View datasheet |
| Link To Supplier | https://www.thermofisher.com |
| Material Safety Data Sheet | Download PDF |
