Transferrin Receptor Monoclonal Antibody (H68.4)
| Catalog Number | Pack Size | List Price* | Quantity | |
|---|---|---|---|---|
| 136890 | 500 µg | 1'382,00 | Add |
* CHF, excl. 8.1% VAT and shipping costs
Product Description
H68.4 is specific to residues 3-28 of the human transferrin receptor (TfR) tail. Cellular uptake of iron occurs via receptor-mediated endocytosis of ligand-occupied transferrin receptor into specialized endosomes. Endosomal acidification leads to iron release. The apotransferrin-receptor complex is then recycled to the cell surface with a return to neutral pH and the concomitant loss of affinity of apotransferrin for its receptor. Transferrin receptor is necessary for development of erythrocytes and the nervous system. Serum transferrin receptor (sTfR) is used as a means of detecting erythropoietin (EPO) misuse by athletes and as a diagnostic test for anemias resulting from a number of conditions including rheumatoid arthritis, pregnancy, irritable bowel syndrome and in HIV patients.
| Category | Antibody |
| Supplier | ThermoFisher |
| Application | EL, ICC, IHC, IP, WB |
| Regulatory Status | RUO |
| Research Field | PROTEIN & CELL ANALYSIS |
| Immunogen | Recombinant human transferrin receptor. |
| Host | Ms |
| Clone Number | [H68.4] |
| Genebank | TFRC |
| Isotype | IgG1 |
| Crossreactivity | Ck, Hm, Hu, Ms, Rt |
| Clonality | Mab |
| Format | Liquid; PBS; pH 7.4, with 0.1% sodium azide |
| Concentration | 0.5 mg/mL |
| Working Dilution | Western Blot (0.5 µg/mL), Immunocytochemistry (1:250), Immunomicroscopy (Assay-dependent), Immuno... |
| Purity | Affinity chromatography |
| Conjugation | Unconjugated |
| Storage Conditions | Freezer (-5 to -30 C) |
| Disclaimer | Alternative CatNo: 13-6890 |
| Tech. Data Sheet | View datasheet |
| Link To Supplier | https://www.thermofisher.com |
| Shipping Details | Ambient |
| Material Safety Data Sheet | Download PDF |
