TGF beta-1,2,3 Monoclonal Antibody (1D11.16.8), Functional Grade, eBioscience™
Catalog Number | Pack Size | List Price* | Quantity | |
---|---|---|---|---|
16-9243-85 | 500 µg | 602,00 | Add |
* CHF, excl. 8.1% VAT and shipping costs
Product Description
Description: The monoclonal antibody 1D11.16.8 recognizes human, mouse, rat, hamster, canine and non-human primate Transforming Growth Factor (TGF) beta 1, 2 and 3. TGF beta is a pleiotropic cytokine that exists as five isoforms (TGF beta 1-5) that share 70-80% homology with each other. However, these isoforms are not homologous to TGF alpha. TGF beta 1 is highly conserved between human, murine, simian, bovine, porcine, and chicken proteins. TGF beta 1 is the most abundant isoform and is ubiquitously expressed by a variety of cell types, including platelets, macrophages, lymphocytes, endothelial cells, chondrocytes, and leukemic cells. However, the other isoforms exhibit a more restricted expression pattern. TGF beta 1 is synthesized as a long precursor polypeptide, which is cleaved to yield the mature protein and the Latency Associated Peptide (LAP). LAP and mature TGF beta 1 remain non-covalently associated during secretion, forming homodimers known as the Small Latent Complex (SLC). Secretion can be induced by steroids, retinoids, EGF, NGF, vitamin D3, and IL-1. The bioactivity of mature TGF beta 1 is dependent on its release from LAP by conformational changes and proteolytic processing. Its activities include inhibition of cell growth in epithelial cells, end
Category | Antibody |
Supplier | ThermoFisher |
Application | IHC, N |
Regulatory Status | RUO |
Host | Ms |
Clone Number | [1D11.16.8] |
Genebank | TGFB1 |
Isotype | IgG1 |
Crossreactivity | Dg, Hm, Hu, Ms, Primate, Rt, Rhesus Monkey |
Clonality | Mab |
Format | Liquid; PBS; pH 7.2, with no preservative |
Concentration | 1 mg/mL |
Working Dilution | Neutralization (Assay-Dependent), Immunohistochemistry (Paraffin) (Assay-Dependent), Functional A... |
Purity | Affinity chromatography |
Storage Conditions | 4° C |
Disclaimer | Alternative CatNo: 16924385 |
Tech. Data Sheet | View datasheet |
Link To Supplier | https://www.thermofisher.com |
Material Safety Data Sheet | Download PDF |