CD369 (Clec7a, Dectin-1) Monoclonal Antibody (15E2), Functional Grade, eBioscience™
Catalog Number | Pack Size | List Price* | Quantity | |
---|---|---|---|---|
16-9856-82 | 100 µg | 267,00 | Add |
* CHF, excl. 8.1% VAT and shipping costs
Product Description
Description: This 15E2 monoclonal antibody reacts with human and non-human primate CD369, which is also known as the Dectin-1 or beta-glucan receptor or CLEC7A. CD369 is expressed predominantly on monocytes, macrophages, and dendritic cells. Moreover, this receptor can also be detected on neutrophils and lymphocytes, as well as induced by cytokines such as IL-4 or LPS. In humans, CD369 exists as two isoforms that arise due to alternative splicing. CD369 binds beta-1,3-glucan and plays an important role in activating signal transduction involved in the innate immune response to fungal and mycobacterial infections. Studies have also shown the involvement of CD369 in dendritic cell activation. The 15E2 monoclonal antibody has been reported to recognize both isoforms of CD369 and activate dendritic cells. It does not crossreact to mouse CD369. Applications Reported: The 15E2 antibody has been reported to activate dendritic cells. Applications Tested: This 15E2 antibody has been tested by flow cytometric analysis of normal human peripheral blood cells. This can be used at less than or equal to 1 µg per test. A test is defined as the amount (µg) of antibody that will stain a cell sample in a final volume of 100 µL. Cell number should be determined empirically but can r
Category | Antibody |
Supplier | ThermoFisher |
Application | FA |
Regulatory Status | RUO |
Host | Ms |
Clone Number | [15E2] |
Genebank | CLEC7A |
Isotype | IgG2a,k |
Crossreactivity | Hu, Primate |
Clonality | Mab |
Format | Liquid; PBS; pH 7.2, with no preservative |
Concentration | 1 mg/mL |
Working Dilution | Functional Assay (Assay-Dependent) |
Purity | Affinity chromatography |
Storage Conditions | 4° C |
Disclaimer | Alternative CatNo: 16985682 |
Tech. Data Sheet | View datasheet |
Link To Supplier | https://www.thermofisher.com |
Material Safety Data Sheet | Download PDF |