CD217 (IL-17Ra) Monoclonal Antibody (PAJ-17R), APC, eBioscience™


Catalog Number Pack Size List Price* Quantity
17-7182-82 100 µg 480,00 Add

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Product Description

Description: The monoclonal antibody PAJ-17R recognizes mouse IL-17 receptor A (IL-17RA) also known as CD217. This single transmembrane domain-containing receptor can homo- or heterodimerize with IL-17RC or IL-17RB. IL-17RA binds to IL-17A, IL-17F(cytokines of the Th 17 lineage), or IL-17E (IL-25). Ligand binding to the single subunit of IL-17RA has been shown to induce homo- or heterodimerization of the receptor complex that in turn recruits Act-1 via the SEFIR domains leading to recruitment of TRAF6 and signaling through the NFkappaB and MAPK pathways. Initial reports suggested ubiquitous expression of IL-17RA based on binding studies with IL-17-Fc and expression of mRNA. Interestingly, despite this, not all cells expressing the receptor respond to IL-17A. In particular, resting T cells do not respond. It is not known if the expression level of IL-17RA protein varies or if some cells express the receptor but are not able to activate downstream signaling events. Recent evidence suggests a more limited expression profile based on IL-17RA knock-out mice which display decreased numbers of neutrophils with impaired function in response to challenge with K. pneumonia or Candida albicans. This suggests IL-17RA plays a more dominant and critical role in neutrophil deve

Category Antibody
Supplier ThermoFisher
Application FC
Regulatory Status RUO
Host Rt
Clone Number [PAJ-17R]
Genebank IL17RA
Isotype IgG2a
Crossreactivity Ms
Clonality Mab
Format Liquid; PBS; pH 7.2, with 0.09% sodium azide
Concentration 0.2 mg/mL
Working Dilution Flow Cytometry (0.25 µg/test)
Purity Affinity chromatography
Conjugation APC
Storage Conditions 4° C, store in dark, DO NOT FREEZE!
Disclaimer Alternative CatNo: 17718282
Tech. Data Sheet View datasheet
Link To Supplier https://www.thermofisher.com
Material Safety Data Sheet Download PDF