E2F1 Monoclonal Antibody (KH95)
Catalog Number | Pack Size | List Price* | Quantity | |
---|---|---|---|---|
321400 | 100 µg | 600,00 | Add |
* CHF, excl. 8.1% VAT and shipping costs
Product Description
The protein encoded by this gene is a member of the E2F family of transcription factors. The E2F family plays a crucial role in the control of cell cycle and action of tumor suppressor proteins and is also a target of the transforming proteins of small DNA tumor viruses. The E2F proteins contain several evolutionally conserved domains found in most members of the family. These domains include a DNA binding domain, a dimerization domain which determines interaction with the differentiation regulated transcription factor proteins (DP), a transactivation domain enriched in acidic amino acids, and a tumor suppressor protein association domain which is embedded within the transactivation domain. This protein and another 2 members, E2F2 and E2F3, have an additional cyclin binding domain. This protein binds preferentially to retinoblastoma protein pRB in a cell-cycle dependent manner. It can mediate both cell proliferation and p53-dependent/independent apoptosis.
Category | Antibody |
Supplier | ThermoFisher |
Application | ChIP, IHC, IP, WB |
Regulatory Status | RUO |
Immunogen | Recombinant human E2F-1 protein. |
Host | Ms |
Clone Number | [KH95] |
Genebank | E2F1 |
Isotype | IgG2a |
Crossreactivity | Hu, Ms, Rt |
Clonality | Mab |
Format | Liquid; PBS; pH 7.4, with 0.1% sodium azide |
Concentration | 0.5 mg/mL |
Working Dilution | Western Blot (1-3 µg/mL), Immunoprecipitation (2-5 µg), Immunohistochemistry (0.1-1.0 µg/mL), ChI... |
Purity | Protein A |
Conjugation | Unconjugated |
Storage Conditions | -20°C |
Disclaimer | Alternative CatNo: 32-1400 |
Tech. Data Sheet | View datasheet |
Link To Supplier | https://www.thermofisher.com |
Material Safety Data Sheet | Download PDF |