IFN beta Polyclonal Antibody

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Product Description

Specificity: Neutralizes mouse interferon beta. Activity: 1.55x10^6 NU/mL. Interferon was titrated with the use of the cytopathic effect inhibition assay using L929 cells with EMCV, where 2.5 unit/mL of interferon was necessary to produce an endpoint of 50%. One neutralization unit is defined as the amount of serum required to neutralize one unit of mouse IFN beta to an endpoint of 50%. For retention of full activity, do not store above -70ºC. Packaged by and distributed for PBL Assay Science. Type I Interferons (IFN-alpha/beta) are produced primarily in response to viral infection by Natural IFN-producing cells (IPCs) as part of the host immune response. IFNs can also inhibit the development of tumors. IFN-beta binding results in the activation of the tyrosine kinases Jak1 and Tyk2, phosphorylation of members of the STAT family of transcription factors, and the transcription and expression of the immune response genes. More recently, several members of the toll-like receptor (TLR) family were found to stimulate the production IFN-beta. IFN-beta is currently used clinically for treatment of tumors, infections and multiple sclerosis.