PLK1 Antibody Cocktail
| Catalog Number | Pack Size | List Price* | Quantity | |
|---|---|---|---|---|
| 331700 | 100 µg | 658,00 | Add |
* CHF, excl. 8.1% VAT and shipping costs
Product Description
33-1700 contains a cocktail of monoclonal mouse PLK1 containing clone PL6, isotype IgG1, kappa and clone PY20, isotype IgG2b, kappa. PLK1 is a Serine/threonine-protein kinase that performs several important functions throughout M phase of the cell cycle, including the regulation of centrosome maturation and spindle assembly, the removal of cohesins from chromosome arms, the inactivation of anaphase-promoting complex/cyclosome (APC/C) inhibitors, and the regulation of mitotic exit and cytokinesis. Polo-like kinase proteins acts by binding and phosphorylating proteins are that already phosphorylated on a specific motif recognized by the POLO box domains. Phosphorylates BORA, BUB1B/BUBR1, CCNB1, CDC25C, CEP55, ECT2, ERCC6L, FBXO5/EMI1, FOXM1, KIF20A/MKLP2, CENPU, NEDD1, NINL, NPM1, NUDC, PKMYT1/MYT1, KIZ, PPP1R12A/MYPT1, PRC1, RACGAP1/CYK4, SGOL1, STAG2/SA2, TEX14, TOPORS, p73/TP73, TPT1 and WEE1. Plays a key role in centrosome functions and the assembly of bipolar spindles by phosphorylating KIZ, NEDD1 and NINL.
| Category | Antibody |
| Supplier | ThermoFisher |
| Application | EL, ICC, IHC, IP, WB |
| Regulatory Status | RUO |
| Research Field | PROTEIN & CELL ANALYSIS |
| Immunogen | A His-tagged Plk fusion protein (C-term Plk1) containing amino acids 402-603 of the human Plk1 protein( |
| Host | Ms |
| Clone Number | [PL6/PL2] |
| Genebank | PLK1 |
| Isotype | mix |
| Crossreactivity | Hu, Ms, Primate, Rt, Xenopus |
| Format | Liquid; PBS; pH 7.4, with 0.1% sodium azide |
| Concentration | 0.5 mg/mL |
| Working Dilution | Immunoprecipitation (5 µg), ELISA (0.1-1.0 µg/mL), Western Blot (1-2 µg/mL), Immunocytochemistry ... |
| Purity | Protein A |
| Conjugation | Unconjugated |
| Storage Conditions | Freezer (-5 to -30 C) |
| Disclaimer | Alternative CatNo: 33-1700 |
| Tech. Data Sheet | View datasheet |
| Link To Supplier | https://www.thermofisher.com |
| Shipping Details | Ambient |
| Material Safety Data Sheet | Download PDF |
