ZO-1 Monoclonal Antibody (ZO1-1A12), Alexa Fluor™ 594
| Catalog Number | Pack Size | List Price* | Quantity | |
|---|---|---|---|---|
| 339194 | 100 µg | 684,00 | Add |
* CHF, excl. 8.1% VAT and shipping costs
Product Description
ZO-1 forms complexes with either ZO-2 or ZO-3. In addition, these proteins can also associate with claudin, occludin and F-actin, at tight junction stands, where they provide a linkage between the actin cytoskeleton and the tight junction. ZO-1 expression is significantly reduced in many breast cancer lines. ZO-2 and ZO-3 are ubiquitously expressed within epithelial tight junctions, and unlike ZO-1, which is also expressed at cell junctions of cardiac myocytes, ZO-2 is not expressed in nonepithelial tissue. ZO-1 is a protein located on a cytoplasmic membrane surface of intercellular tight junctions. ZO-1 may be involved in signal transduction at cell-cell junctions. Two transcript variants encoding distinct isoforms have been identified for the ZO-1 gene. Diseases associated with ZO-1 dysfunction include Celiac Disease and Congenital Nephrotic Syndrome.
| Category | Antibody |
| Supplier | ThermoFisher |
| Application | EL, ICC, WB |
| Regulatory Status | RUO |
| Immunogen | Human recombinant ZO-1 fusion protein encompassing amino acids 334-634 |
| Host | Ms |
| Clone Number | [ZO1-1A12] |
| Genebank | TJP1 |
| Isotype | IgG1,k |
| Crossreactivity | Dg, Hu |
| Clonality | Mab |
| Format | Liquid; PBS; pH 7.4, with 4.0mg/mL BSA and 0.1% sodium azide |
| Concentration | 0.5 mg/mL |
| Working Dilution | Immunocytochemistry (1-10 µg/mL), ELISA (0.1-1.0 µg/mL), Western Blot (1-2 µg/mL) |
| Purity | Protein A |
| Conjugation | Alexa Fluor 594 |
| Storage Conditions | 4° C, store in dark |
| Tech. Data Sheet | View datasheet |
| Link To Supplier | https://www.thermofisher.com |
| Material Safety Data Sheet | Download PDF |
