NOTCH1 Monoclonal Antibody (mN1A)

* CHF, excl. 8.1% VAT and shipping costs

Product Description

This antibody is specific for the Notch1 (neurogenic locus notch homolog protein1, Motch A, mT14, p300) protein. This antibody gives a band of ~65 kDa on Western blot analysis using Notch1-IC OP transfected cells. Western blot analysis using Jurkat cells expresses the target band at ~110-120 kDa, with an additional band occasionally observed at ~220kDa. This antibody does not cross-react with Notch 2,3, and 4 as assessed by Western blot analysis. The notch gene belongs to a family of epidermal growth factor (EGF) like homeotic genes, which encode transmembrane proteins with a variable number of cysteine-rich EGF-like repeats in the extracellular region. Four notch genes have been described in mammals: Notch1, Notch2, Notch3 and Notch4(Int-3), which have been implicated in the differentiation of the nervous system and other structures. The EGF-like proteins Delta and Serrate have been identified as ligands of Notch1. Mature Notch proteins are heterodimeric receptors derived from the cleavage of Notch pre-proteins into an extracellular subunit (NEC) containing multiple EGF-like repeats and a transmembrane subunit including intracellular region (Ntm).