LXR alpha Monoclonal Antibody (K8607)
Catalog Number | Pack Size | List Price* | Quantity | |
---|---|---|---|---|
418200 | 100 µL | 700,00 | Add |
* CHF, excl. 8.1% VAT and shipping costs
Product Description
This antibody specifically recognizes LXR alpha but does not recognize human LXR beta. NR1H3 (oxysterols receptor LXR-alpha) is a nuclear receptor that exhibits a ligand-dependent transcriptional activation activity. Its interaction with retinoic acid receptor (RXR) shifts RXR from its role as a silent DNA-binding partner to an active ligand-binding subunit in mediating retinoid responses through target genes defined by LXRES. LXRES are DR4-type response elements characterized by direct repeats of two similar hexanucleotide half-sites spaced by four nucleotides. NR1H3 plays an important role in the regulation of cholesterol homeostasis, regulating cholesterol uptake through MYLIP-dependent ubiquitination of LDLR, VLDLR, and LRP8. It also interplays functionally with RORA for the regulation of genes involves in liver metabolism.
Category | Antibody |
Supplier | ThermoFisher |
Application | ChIP, EL, IP, WB |
Regulatory Status | RUO |
Immunogen | Produced in BALB/c mouse ascites after inoculation with hybridoma of mouse myeloma cells (NS-1) and spleen cells derived from a BALB/c mouse immunized with Baculovirus-expressed recombinant human L... |
Host | Ms |
Clone Number | [K8607] |
Genebank | NR1H3 |
Isotype | IgG2a |
Crossreactivity | Hu |
Clonality | Mab |
Format | Liquid; physiological saline; , with 0.1% sodium azide |
Concentration | 1 mg/mL |
Working Dilution | Immunoprecipitation (Assay-dependent), Western Blot (2 µg/mL), Gel Shift (Assay-dependent), ELISA... |
Purity | Ammonium sulfate precipitation |
Conjugation | Unconjugated |
Storage Conditions | Maintain refrigerated at 2-8°C for up to 1 month. For long term storage store at -20°C |
Tech. Data Sheet | View datasheet |
Link To Supplier | https://www.thermofisher.com |
Material Safety Data Sheet | Download PDF |