LXR alpha Monoclonal Antibody (K8607)


Catalog Number Pack Size List Price* Quantity
418200 100 µL 700,00 Add

* CHF, excl. 8.1% VAT and shipping costs


Product Description

This antibody specifically recognizes LXR alpha but does not recognize human LXR beta. NR1H3 (oxysterols receptor LXR-alpha) is a nuclear receptor that exhibits a ligand-dependent transcriptional activation activity. Its interaction with retinoic acid receptor (RXR) shifts RXR from its role as a silent DNA-binding partner to an active ligand-binding subunit in mediating retinoid responses through target genes defined by LXRES. LXRES are DR4-type response elements characterized by direct repeats of two similar hexanucleotide half-sites spaced by four nucleotides. NR1H3 plays an important role in the regulation of cholesterol homeostasis, regulating cholesterol uptake through MYLIP-dependent ubiquitination of LDLR, VLDLR, and LRP8. It also interplays functionally with RORA for the regulation of genes involves in liver metabolism.

Category Antibody
Supplier ThermoFisher
Application ChIP, EL, IP, WB
Regulatory Status RUO
Immunogen Produced in BALB/c mouse ascites after inoculation with hybridoma of mouse myeloma cells (NS-1) and spleen cells derived from a BALB/c mouse immunized with Baculovirus-expressed recombinant human L...
Host Ms
Clone Number [K8607]
Genebank NR1H3
Isotype IgG2a
Crossreactivity Hu
Clonality Mab
Format Liquid; physiological saline; , with 0.1% sodium azide
Concentration 1 mg/mL
Working Dilution Immunoprecipitation (Assay-dependent), Western Blot (2 µg/mL), Gel Shift (Assay-dependent), ELISA...
Purity Ammonium sulfate precipitation
Conjugation Unconjugated
Storage Conditions Maintain refrigerated at 2-8°C for up to 1 month. For long term storage store at -20°C
Tech. Data Sheet View datasheet
Link To Supplier https://www.thermofisher.com
Material Safety Data Sheet Download PDF