LXR alpha Monoclonal Antibody (PPZ0412)
| Catalog Number | Pack Size | List Price* | Quantity | |
|---|---|---|---|---|
| 418300 | 100 µL | 636,00 | Add |
* CHF, excl. 8.1% VAT and shipping costs
Product Description
This antibody specifically recognizes human LXR alpha and cross reacts with mouse and rat LXR alpha. This antibody does not recognize human LXR beta. NR1H3 (oxysterols receptor LXR-alpha) is a nuclear receptor that exhibits a ligand-dependent transcriptional activation activity. Its interaction with retinoic acid receptor (RXR) shifts RXR from its role as a silent DNA-binding partner to an active ligand-binding subunit in mediating retinoid responses through target genes defined by LXRES. LXRES are DR4-type response elements characterized by direct repeats of two similar hexanucleotide half-sites spaced by four nucleotides. NR1H3 plays an important role in the regulation of cholesterol homeostasis, regulating cholesterol uptake through MYLIP-dependent ubiquitination of LDLR, VLDLR, and LRP8. It also interplays functionally with RORA for the regulation of genes involves in liver metabolism.
| Category | Antibody |
| Supplier | ThermoFisher |
| Application | ChIP, EL, IHC, IP, WB |
| Regulatory Status | RUO |
| Immunogen | Produced in BALB/c mouse ascites after inoculation with hybridoma of mouse myeloma cells (NS-1) and spleen cells derived from a BALB/c mouse immunized with E.coli-expressed recombinant human LXR-al... |
| Host | Ms |
| Clone Number | [PPZ0412] |
| Genebank | NR1H3 |
| Isotype | IgG2a |
| Crossreactivity | Hu, Ms, Rt |
| Clonality | Mab |
| Format | Liquid; physiological saline; , with 0.1% sodium azide |
| Concentration | 1 mg/mL |
| Working Dilution | Gel Shift (Assay-dependent), Immunoprecipitation (Assay-dependent), ChIP Assay (Assay-dependent),... |
| Purity | Ammonium sulfate precipitation |
| Conjugation | Unconjugated |
| Storage Conditions | Maintain refrigerated at 2-8°C for up to 1 month. For long term storage store at -20°C |
| Tech. Data Sheet | View datasheet |
| Link To Supplier | https://www.thermofisher.com |
| Material Safety Data Sheet | Download PDF |
