RXRA Monoclonal Antibody (K8508)
Catalog Number | Pack Size | List Price* | Quantity | |
---|---|---|---|---|
433900 | 100 µL | 762,00 | Add |
* CHF, excl. 8.1% VAT and shipping costs
Product Description
This antibody specifically recognizes human RXR alpha and cross reacts with mouse and rat RXR alpha. This antibody does not recognize human RXR beta and gamma. Retinoic Acid (RA; active metabolite of vitamin A) plays a prominent role in regulating the transition of proliferating precursor cells (such as carcinoma cells and neuronal precursors) to postmitotic differentiated cells. The Retinoid X Receptors (RXRs) family (RXR alpha, beta, and gamma), preferentially bind 9-cis -RA and regulate gene transcription by forming heterodimers with a second family of RA receptors. RAs have been suggested to potentially play a therapeutic role in cervical cancer. RAs are known to play key roles in neuronal development and an increasing body of evidence indicates that retinoid signaling may regulate synaptic plasticity and associated learning and memory behaviors.
Category | Antibody |
Supplier | ThermoFisher |
Application | ChIP, EL, ICC, IHC, IP, WB |
Regulatory Status | RUO |
Immunogen | Produced in BALB/c mouse ascites after inoculation with hybridoma of mouse myeloma cells (NS-1) and spleen cells derived from a BALB/c mouse immunized with Baculovirus-expressed recombinant human R... |
Host | Ms |
Clone Number | [K8508] |
Genebank | RXRA |
Isotype | IgG2a |
Crossreactivity | Hu, Ms, Rt |
Clonality | Mab |
Format | Liquid; physiological saline; , with 0.1% sodium azide |
Concentration | 1 mg/mL |
Working Dilution | Immunoprecipitation (Assay-dependent), Western Blot (2 µg/mL), Gel Shift (Assay-dependent), ELISA... |
Purity | Ammonium sulfate precipitation |
Conjugation | Unconjugated |
Storage Conditions | Maintain refrigerated at 2-8°C for up to 1 month. For long term storage store at -20°C |
Tech. Data Sheet | View datasheet |
Link To Supplier | https://www.thermofisher.com |
Material Safety Data Sheet | Download PDF |