CYLD Monoclonal Antibody (733)
| Catalog Number | Pack Size | List Price* | Quantity | |
|---|---|---|---|---|
| 437700 | 100 µg | 594,00 | Add |
* CHF, excl. 8.1% VAT and shipping costs
Product Description
CYLD is a 956 aa, cytoplasmic, deubiquitinating enzyme belonging to the ubiquitin carboxy-terminal hydrolases (UCH) family of proteins with three cytoskeletal-associated protein-glycine-conserved (CAP-GLY) domains, a proline rich region, a SH3 binding domain and a sequence homology to catalytic domain of UCH. CYLD is identified as a tumor suppressor protein affecting the JNK signaling pathway. CYLD is a negative regulator of TRAF2 and NF-kappa-B signaling pathway and is also known to have receptor-dependent role in regulating the I-kappa-B kinase pathway. It also has a deubiquitinating activity that is directed towards non-Lys-48-linked polyubiquitin chains and TRAP1 is a novel substrate for deubiquitination. Mutated CYLD is known to be associated with cylindromatosis, multiple familial trichoepithelioma, and Brooke-Spiegler syndrome.
| Category | Antibody |
| Supplier | ThermoFisher |
| Application | ICC, IHC, WB |
| Regulatory Status | RUO |
| Immunogen | Recombinant protein derived from the N-terminus of human CYLD protein |
| Host | Ms |
| Clone Number | [733] |
| Genebank | CYLD |
| Isotype | IgG1 |
| Crossreactivity | Bo, Ho, Hu, Ms, Primate, Rt |
| Clonality | Mab |
| Format | Liquid; PBS; pH 7.4, with 0.1% sodium azide |
| Concentration | 0.5 mg/mL |
| Working Dilution | Western Blot (1:1,000), Immunohistochemistry (Paraffin) (1:10-1:50), Immunocytochemistry (1 µg/mL) |
| Purity | Protein A |
| Conjugation | Unconjugated |
| Storage Conditions | Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. |
| Disclaimer | Alternative CatNo: 43-7700 |
| Tech. Data Sheet | View datasheet |
| Link To Supplier | https://www.thermofisher.com |
| Material Safety Data Sheet | Download PDF |
