Caspase 3 Monoclonal Antibody (74T2)
Catalog Number | Pack Size | List Price* | Quantity | |
---|---|---|---|---|
437800 | 100 µg | 598,00 | Add |
* CHF, excl. 8.1% VAT and shipping costs
Product Description
This gene encodes a protein which is a member of the cysteine-aspartic acid protease (caspase) family. Sequential activation of caspases plays a central role in the execution-phase of cell apoptosis. Caspases exist as inactive proenzymes which undergo proteolytic processing at conserved aspartic residues to produce two subunits, large and small, that dimerize to form the active enzyme. This protein cleaves and activates caspases 6, 7 and 9, and the protein itself is processed by caspases 8, 9 and 10. It is the predominant caspase involved in the cleavage of amyloid-beta 4A precursor protein, which is associated with neuronal death in Alzheimer's disease. Alternative splicing of this gene results in two transcript variants that encode the same protein.
Category | Antibody |
Supplier | ThermoFisher |
Application | ICC, IHC, IP, WB |
Regulatory Status | RUO |
Immunogen | Recombinant protein derived from the N-terminus of human Caspase 3 protein |
Host | Ms |
Clone Number | [74T2] |
Genebank | CASP3 |
Isotype | IgG1 |
Crossreactivity | Ho, Hu, Ms, Primate, Rt |
Clonality | Mab |
Format | Liquid; PBS; pH 7.4, with 0.1% sodium azide |
Concentration | 0.5 mg/mL |
Working Dilution | Immunocytochemistry (2 µg/mL), Immunoprecipitation (Assay-dependent), Immunohistochemistry (Paraf... |
Purity | Protein A |
Conjugation | Unconjugated |
Storage Conditions | Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. |
Disclaimer | Alternative CatNo: 43-7800 |
Tech. Data Sheet | View datasheet |
Link To Supplier | https://www.thermofisher.com |
Material Safety Data Sheet | Download PDF |