beta Amyloid (1-43) Polyclonal Antibody

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Product Description

This beta Amyloid (1-43) antibody (44-340) is purified from rabbit serum by epitope-specific affinity chromatography. Any reactivity towards both full length A beta 40 and A beta 42 protein has been eliminated through a series of preabsorption steps. This antibody shows no significant cross-reactivity against A beta 40 or A beta 42. Amyloid beta peptide (Abeta/Beta-amyloid) is the major constituent of amyloid plaques in the brains of individuals afflicted with Alzheimer's disease. Abeta peptide is 40-43 amino acids long and generated from the beta-amyloid precursor protein (beta APP) in a two-step process. The first step involves cleavage of the extracellular, amino-terminal domain of beta APP. Protein cleavage is performed by an aspartyl protease, beta-secretase (BACE) which is synthesized as a propeptide and must be modified to the mature and active form by the prohormone convertase, furin. Beta APP cleavage by the mature form of BACE results in the cellular secretion of a segment of beta APP, and a membrane-bound remnant. The remnant protein is processed by another protease, gamma-secretase. Gamma-secretase cleaves an intra-membrane site in the carboxyl-terminal domain of beta APP, thus generating the amyloid beta peptide. Gamma-secretase is believed to be a m