Phospho-SRC (Tyr419) Polyclonal Antibody, Alexa Fluor™ 488
Catalog Number | Pack Size | List Price* | Quantity | |
---|---|---|---|---|
44660A1 | 100 µL | 592,00 | Add |
* CHF, excl. 8.1% VAT and shipping costs
Product Description
SRC is a non-receptor kinase involved in the regulation of growth and differentiation of eukaryotic cells. SRC associates with the cytoplasmic region of various cell surface receptors to facilitate signal transduction, and is also involved in cytoskeletal organization, cell cycle regulation, and apoptosis. In humans, the gene encoding SRC is present on chromosome 20. Activity of SRC is regulated by two tyrosine residues (Tyr 416 and Tyr527), and phosphorylation of these two sites have opposing effects. Phosphorylation of Tyr416 in the activation loop of the kinase domain upregulates enzyme activity while the phosphorylation of Tyr527 decreases enzyme activity. Mutations in the SRC gene could be involved in the malignant progression of colon cancer. Two transcript variants encoding the same SRC protein have been found thus far.
Category | Antibody |
Supplier | ThermoFisher |
Application | ICC |
Regulatory Status | RUO |
Immunogen | This antibody was produced against a chemically synthesized phosphopeptide derived from the region of Src that contains tyrosine 419. The antibody was affinity purified by sequential epitope-specif... |
Host | Rb |
Genebank | SRC |
Isotype | IgG |
Crossreactivity | Dg, Ck, Hu, Ms |
Clonality | Pab |
Format | Liquid; Dulbecco's PBS; pH 7.3, with 0.2mg/mL BSA and 0.05% sodium azide |
Concentration | 1 mg/mL |
Working Dilution | Immunocytochemistry (1:250) |
Purity | purified |
Conjugation | Alexa Fluor 488 |
Storage Conditions | -20°C |
Disclaimer | Alternative CatNo: 44-660A1 |
Tech. Data Sheet | View datasheet |
Link To Supplier | https://www.thermofisher.com |
Material Safety Data Sheet | Download PDF |