Estrogen Receptor alpha Monoclonal Antibody
Catalog Number | Pack Size | List Price* | Quantity | |
---|---|---|---|---|
491002 | 50 µg | 586,00 | Add |
* CHF, excl. 8.1% VAT and shipping costs
Product Description
Estrogen Receptors (ER) are members of the steroid/thyroid hormone receptor superfamily of nuclear receptors. The estrogen receptor is a ligand-activated transcription factor, that when bound to estrogen hormone, induces a conformational change that allows dimerization and binding to estrogen response elements (ERE) in DNA. When bound to EREs, ER can positively or negatively regulate gene transcription through the recruitment of coactivator or corepressor proteins. There are two different forms of the estrogen receptor, alpha and beta, encoded by separate genes (ESR1 and ESR2, respectively). Due to alternative RNA splicing, at least 4 estrogen receptor-alpha isoforms are known to exist (Isoform 1 (66 kDa), Isoform 2 (53 kDa), Isoform 3 (47 kDa), Isoform 4 (35 kDa)). Estrogen receptors are widely expressed in different tissue types and are essential for sexual development and reproductive function. They also play a role in other tissues such as bone. Estrogen receptors are involved in pathological processes including breast cancer, endometrial cancer, and osteoporosis.
Category | Antibody |
Supplier | ThermoFisher |
Application | ChIP, ICC, WB |
Regulatory Status | RUO |
Immunogen | NH2 terminus of the human estrogen receptor alpha using a peptide antigen (Q19-K32) conjugated to KLH |
Host | Ms |
Genebank | ESR1 |
Isotype | IgG3 |
Crossreactivity | Hu |
Clonality | Mab |
Format | Liquid; PBS; , with 0.01% thimerosal |
Concentration | 2 mg/mL |
Working Dilution | Immunocytochemistry (15 µg/mL), ChIP Assay (5 µg), Western Blot (7 µg/mL) |
Purity | Ammonium sulfate precipitation |
Conjugation | Unconjugated |
Storage Conditions | -20° C, Avoid Freeze/Thaw Cycles |
Disclaimer | Alternative CatNo: 49-1002 |
Tech. Data Sheet | View datasheet |
Link To Supplier | https://www.thermofisher.com |
Material Safety Data Sheet | Download PDF |