H3K27me2 Polyclonal Antibody
| Catalog Number | Pack Size | List Price* | Quantity | |
|---|---|---|---|---|
| 491013 | 50 µg | 586,00 | Add |
* CHF, excl. 8.1% VAT and shipping costs
Product Description
Histone H3 is one of the DNA-binding proteins found in the chromatin of all eukaryotic cells. H3 along with four core histone proteins binds to DNA forming the structure of the nucleosome. Histones play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. Post translationally, histones are modified in a variety of ways to either directly change the chromatin structure or allow for the binding of specific transcription factors. The N-terminal tail of histone H3 protrudes from the globular nucleosome core and can undergo several different types of post-translational modification that influence cellular processes. These modifications include the covalent attachment of methyl or acetyl groups to lysine and arginine amino acids and the phosphorylation of serine or threonine.
| Category | Antibody |
| Supplier | ThermoFisher |
| Application | DB, EL, ICC, WB |
| Regulatory Status | RUO |
| Immunogen | Raised against the region of the histone H3 containing the dimethylated lysine 27 (H3K27me2), using a KLH-conjugated synthetic peptide. |
| Host | Rb |
| Genebank | H3C1 |
| Isotype | IgG |
| Crossreactivity | Hu, Zebrafish |
| Clonality | Pab |
| Format | Liquid; PBS; , with 0.05% ProClin 300, 0.05% sodium azide |
| Concentration | 2.63 mg/mL |
| Working Dilution | Dot Blot (1:50,000), Western Blot (1:1,000), Immunocytochemistry (1:500), ELISA (1:1,000) |
| Purity | Affinity chromatography |
| Conjugation | Unconjugated |
| Storage Conditions | -20° C, Avoid Freeze/Thaw Cycles |
| Disclaimer | Alternative CatNo: 49-1013 |
| Tech. Data Sheet | View datasheet |
| Link To Supplier | https://www.thermofisher.com |
| Material Safety Data Sheet | Download PDF |
