RNA pol II CTD Monoclonal Antibody
| Catalog Number | Pack Size | List Price* | Quantity | |
|---|---|---|---|---|
| 491033 | 100 µL | 594,00 | Add |
* CHF, excl. 8.1% VAT and shipping costs
Product Description
RNA polymerase II is the enzyme responsible for the synthesis of mRNA and many non-coding RNAs. POLR2A encodes RNA polymerase II subunit B1 (RPB1), the largest subunit of RNA polymerase II. The C-terminal domain (CTD) of RPB1 contains tandem heptapeptide repeats with the consensus sequence YSPTSPS. Phosphorylation and other modifications within this sequence influence the recruitment of factors that regulate the transcription cycle. Recruitment of RNA processing factors to the elongation complex is coordinated by the phosphorylation of Serine-2 and Serine-5 residues within the CTD.
| Category | Antibody |
| Supplier | ThermoFisher |
| Application | ChIP, ICC, WB |
| Regulatory Status | RUO |
| Immunogen | Raised against the largest subunit of RNA polymerase II of wheat germ and interacts with the highly conserved C-terminal domain of this protein containing the repeat YSPTSPS. |
| Host | Ms |
| Genebank | POLR2A |
| Isotype | IgG2a |
| Crossreactivity | Hu, Ms, Xenopus |
| Clonality | Mab |
| Format | Liquid; ascites; , with <0.1% sodium azide |
| Working Dilution | ChIP-Sequencing (2 µL/1x10^6 cells), Western Blot (1:500 - 1:1000), Immunocytochemistry (1:100), ... |
| Conjugation | Unconjugated |
| Storage Conditions | -20° C, Avoid Freeze/Thaw Cycles |
| Disclaimer | Alternative CatNo: 49-1033 |
| Tech. Data Sheet | View datasheet |
| Link To Supplier | https://www.thermofisher.com |
| Material Safety Data Sheet | Download PDF |
