Desmin Monoclonal Antibody (DE-U-10), eFluor™ 660, eBioscience™
Catalog Number | Pack Size | List Price* | Quantity | |
---|---|---|---|---|
50-9747-82 | 100 µg | 558,00 | Add |
* CHF, excl. 8.1% VAT and shipping costs
Product Description
Description: The monoclonal antibody DE-U-10 recognizes desmin. Desmin is the protein subunit of class-III intermediate filaments. Desmin is found predominantly in skeletal, cardiac, and smooth muscle. Desmin plays a role in muscle cell development and differentiation, muscle cell architecture and structure, and mitochondrial function. Desmin forms scaffolds around the Z-disk of sarcomeres in muscle cells. Desmin knockout mice exhibit defects in skeletal, smooth, and cardiac muscle and have impaired mitochondrial function. Mutations in Desmin result in conditions such as desmin-related myopathy (DRM), cardiomyopathy dilated type 1I (CMD1I), and neurogenic scapuloperoneal syndrome Kaeser type (Kaeser syndrome). The DE-U-10 antibody recognizes human, mouse, rat, feline, bovine, goat, hamster, sheep, porcine, rabbit, and chicken desmin. The DE-U-10 antibody will also label tumors derived from muscle tissue, such as leiomyomas and rhabdomyosarcomas. Applications Reported: This DE-U-10 antibody has been reported for use in immunohistochemical staining of formalin-fixed paraffin embedded tissue sections, microscopy, and immunocytochemistry. Applications Tested: This DE-U-10 antibody has been tested by immunohistochemistry of formalin-fixed paraffin embedded human tissu
Category | Antibody |
Supplier | ThermoFisher |
Application | ICC, IHC |
Regulatory Status | RUO |
Host | Ms |
Clone Number | [DE-U-10] |
Genebank | DES |
Isotype | IgG1,k |
Crossreactivity | Bo, Ck, Ca, Gt, Hm, Hu, Ms, Sh, Pg, Rb, Rt |
Clonality | Mab |
Format | Liquid; PBS; pH 7.2, with 0.09% sodium azide |
Concentration | 0.2 mg/mL |
Working Dilution | Immunohistochemistry (Paraffin) (10 µg/mL), Immunocytochemistry (10 µg/mL) |
Purity | Affinity chromatography |
Conjugation | eFluor 660 |
Storage Conditions | 4° C, store in dark, DO NOT FREEZE! |
Disclaimer | Alternative CatNo: 50974782 |
Tech. Data Sheet | View datasheet |
Link To Supplier | https://www.thermofisher.com |
Material Safety Data Sheet | Download PDF |