CD209a Monoclonal Antibody (MMD3), Alexa Fluor™ 488, eBioscience™

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Product Description

Description: This MMD3 monoclonal antibody recognizes mouse CD209a, which is also known as DC-SIGN. CD209a is a type II transmembrane C-type lectin expressed on a subset of dendritic cells, including some CD4+, CD8- and plasmacytoid pre-dendritic cells. Studies indicate that CD209a expression can vary according to the activation state of the host. Moreover, CD209a is down-regulated in spleen-derived dendritic cell cultures supplemented with GM-CSF. CD209a is involved in mediating the innate immune response by binding microbial carbohydrates. Cross-blocking studies suggest that MMD3 recognizes a different a different epitope from LWC06 and 5H10. Applications Reported: This MMD3 antibody has been reported for use in immunohistochemical staining of frozen tissue sections, microscopy, immunohistochemical staining, and immunocytochemistry. Applications Tested: This MMD3 antibody has been tested by immunohistochemistry on frozen 5-week-old mouse thymus and can be used at less than or equal to 20 µg/mL. It is recommended that the antibody be carefully titrated for optimal performance in the assay of interest. Excitation: 488 nm; Emission: 519 nm; Laser: Blue Laser. Filtration: 0.2 µm post-manufacturing filtered. This gene encodes a transmembrane receptor and is of