CD278 (ICOS) Monoclonal Antibody (C398.4A), Super Bright™ 436, eBioscience™
Catalog Number | Pack Size | List Price* | Quantity | |
---|---|---|---|---|
62-9949-82 | 100 µg | 389,00 | Add |
* CHF, excl. 8.1% VAT and shipping costs
Product Description
Description: The C398.4A monoclonal antibody reacts with ICOS (Inducible Costimulatory molecule), also known as H4/CRP-1/AILIM, and cross-reacts with mouse and rat ICOS. ICOS is a T cell specific activation molecule and a third member of the CD28/CTLA-4 family. A dimer of 47-57 kDa, ICOS is expressed on activated T cells, has potent costimulatory activity for T cell activation and proliferation and is required for humoral immune response. ICOS binds to its ligand on activated APC including B cells called B7h/B7RP-1, is thought to play a protective role in inflammatory autoimmune diseases and be involved in the development of Th2 cells. C398.4A is reported to display strong costimulation of proliferation of T cell clones, intermediate costimulation on activated T cells, and weak costimulation on fresh resting T cells. It is a good costimulator of IL-10 production especially from pre-activated cells that express high level of H4/ICOS. The epitope recognized by C398.4A is different from that bound by the ICOSL (i.e., C398.4A does not block binding of ICOSL). Applications Reported: This C398.4A antibody has been reported for use in flow cytometric analysis. Applications Tested: This C398.4A antibody has been tested by flow cytometric analysis of stimulated mouse sple
Category | Antibody |
Supplier | ThermoFisher |
Application | FC |
Regulatory Status | RUO |
Host | Hm |
Clone Number | [C398.4A] |
Genebank | ICOS |
Isotype | IgG |
Crossreactivity | Ms, Rt, Rhesus Monkey |
Clonality | Mab |
Format | Liquid; PBS; pH 7.2, with BSA and 0.09% sodium azide |
Concentration | 0.2 mg/mL |
Working Dilution | Flow Cytometry (0.5 µg/test) |
Purity | Affinity chromatography |
Conjugation | Other |
Storage Conditions | 4° C, store in dark, DO NOT FREEZE! |
Disclaimer | Alternative CatNo: 62994982 |
Tech. Data Sheet | View datasheet |
Link To Supplier | https://www.thermofisher.com |
Material Safety Data Sheet | Download PDF |