SARS-CoV-2 Spike Protein (RBD) Chimeric Recombinant Rabbit Monoclonal Antibody (P06DHuRb)
Catalog Number | Pack Size | List Price* | Quantity | |
---|---|---|---|---|
703974 | 100 µg | 498,00 | Add |
* CHF, excl. 8.1% VAT and shipping costs
Product Description
This antibody has human Fab with a lambda light chain, and Rabbit Fc. It recognizes the RBD domain of SARS CoV2 Spike protein. It is recommended that the antibody be carefully titrated for optimal performance in the assay of interest. This antibody is not recommended for the Western blot application. SARS-CoV-2 (Severe Acute Respiratory Syndrome Coronavirus 2) also known as 2019-nCoV (2019 Novel Coronavirus) is a virus that causes illnesses ranging from the common cold symptoms to severe effects including death and respiratory distress. The CoV Spike (S) protein plays the most important roles in viral attachment, fusion and entry, and serves as a target for development of antibodies, entry inhibitors and vaccines. Of note is the Spike protein receptor-binding domain (RBD, S-RBD) in SARS-CoV-2 Spike protein which binds strongly to human and bat angiotensin-converting enzyme 2 (ACE2) receptors. SARS-CoV-2 RBD exhibits significantly higher binding affinity to ACE2 receptor than SARS-CoV RBD in comparison. S1 contains a receptor-binding domain (RBD) that can specifically bind to angiotensin-converting enzyme 2 (ACE2), the receptor on target cells.
Category | Antibody |
Supplier | ThermoFisher |
Application | EL, FC, ICC, N |
Regulatory Status | RUO |
Immunogen | This antibody was developed using computationally derived variants of SARS-CoV antibody structures and is shown to bind Spike Protein S1 subunit (RBD) of SARS CoV2 |
Host | Rb |
Clone Number | [P06DHuRb] |
Isotype | IgG,l |
Crossreactivity | Virus |
Clonality | Recombi |
Format | Liquid; PBS; pH 7.4, with 0.09% sodium azide |
Concentration | 0.5 mg/mL |
Working Dilution | Neutralization (0.1 - 10 µg/mL), Flow Cytometry (0.01 µg/test), Immunocytochemistry (5 µg/mL), EL... |
Purity | Protein A |
Conjugation | Unconjugated |
Storage Conditions | -20° C, Avoid Freeze/Thaw Cycles |
Product Line | Coronavirus |
Tech. Data Sheet | View datasheet |
Link To Supplier | https://www.thermofisher.com |
Material Safety Data Sheet | Download PDF |