PAX2 Polyclonal Antibody
Catalog Number | Pack Size | List Price* | Quantity | |
---|---|---|---|---|
716000 | 100 µg | 582,00 | Add |
* CHF, excl. 8.1% VAT and shipping costs
Product Description
The pax genes are a family of transcription factors that are active in specific tissues during early embryonic development. Pax family members possess a DNA-binding domain encoded by the paired box. Because paired domain containing genes encode transcription factors, they are capable of executing a genetic program. Several pax genes have also been associated with developmental mutations including: pax-3, which is associated with Waardenburg syndrome, pax-6, which is associated with Aniridia, and pax-2, which is associated with Wilms tumor. During embryogenesis, Pax-2 is expressed in the developing kidney. In particular, the pax-2 gene is expressed in condensing metanephric mesenchyme and in early epithelial structures derived from mesenchyme; however, pax-2 mRNA and protein levels are rapidly down regulated as the tubular epithelium matures. Although Pax-2 is down regulated during renal epithelium maturation, Pax-2 expression persists in the undifferentiated epithelium of Wilms' tumors. Persistent expression of Pax-2 in Wilms' tumors occurs frequently and correlates with the proliferation of poorly differentiated epithelial cells in these tumors. Interestingly, expression of the Wilms' tumor suppresser protein, WT1, coincides with down-regulation of the pax-2 gen
Category | Antibody |
Supplier | ThermoFisher |
Application | EL, IHC, IP, WB |
Regulatory Status | RUO |
Immunogen | A GST-Pax-2 fusion protein derived from the C-terminal domain (aa188-385) of the murine Pax-2 protein |
Host | Rb |
Genebank | PAX2 |
Isotype | IgG |
Crossreactivity | Hu, Ms, Sh, Rt, Xenopus, Zebrafish |
Clonality | Pab |
Format | Liquid; PBS; pH 7.4, with 0.1% sodium azide |
Concentration | 0.25 mg/mL |
Working Dilution | Western Blot (Assay-dependent), ELISA (Assay-dependent), Immunoprecipitation (Assay-dependent), I... |
Purity | Antigen affinity chromatography |
Conjugation | Unconjugated |
Storage Conditions | -20°C |
Disclaimer | Alternative CatNo: 71-6000 |
Tech. Data Sheet | View datasheet |
Link To Supplier | https://www.thermofisher.com |
Material Safety Data Sheet | Download PDF |