Bcl-xL Monoclonal Antibody (7B2.5), Biotin
Catalog Number | Pack Size | List Price* | Quantity | |
---|---|---|---|---|
A15375 | 100 µg | 682,00 | Add |
* CHF, excl. 8.1% VAT and shipping costs
Product Description
BCL-XL is a part of the BCL-2 protein family. BCL-2 family members form hetero- or homodimers and act as anti- or pro-apoptotic regulators that are involved in a wide variety of cellular activities. BCL-XL is located at the outer mitochondrial membrane, and have been shown to regulate outer mitochondrial membrane channel (VDAC) opening. VDAC regulates mitochondrial membrane potential and controls the production of reactive oxygen species and release of cytochrome C by mitochondria, both of which are the potent inducers of cell apoptosis. Two alternatively spliced transcript variants, which encode distinct isoforms, have been reported. The longer isoform acts as an apoptotic inhibitor and the shorter form acts as an apoptotic activator.
Category | Antibody |
Supplier | ThermoFisher |
Application | FC |
Regulatory Status | RUO |
Immunogen | Recombinant Bcl-xS from Recombinant human Bcl-xS |
Host | Ms |
Clone Number | [7B2.5] |
Genebank | BCL2L1 |
Isotype | IgG3,k |
Crossreactivity | Hu, Ms, Rt, Rhesus Monkey |
Clonality | Mab |
Format | Liquid; PBS; , with <0.1% sodium azide |
Concentration | 0.1 mg/mL |
Working Dilution | Flow Cytometry (3 µg/1x10^6 cells) |
Purity | purified |
Conjugation | Biotin |
Storage Conditions | 4° C |
Tech. Data Sheet | View datasheet |
Link To Supplier | https://www.thermofisher.com |
Material Safety Data Sheet | Download PDF |