TCR beta Monoclonal Antibody (H57-597), Pacific Blue™
Catalog Number | Pack Size | List Price* | Quantity | |
---|---|---|---|---|
A15411 | 100 µg | 419,00 | Add |
* CHF, excl. 8.1% VAT and shipping costs
Product Description
The ability of T cell receptors (TCR) to discriminate foreign from self-peptides presented by major histocompatibility complex (MHC) class II molecules is essential for an effective adaptive immune response. TCR recognition of self-peptides has been linked to autoimmune disease. Mutant self-peptides have been associated with tumors. Engagement of TCRs by a family of bacterial toxins know as superantigens has been responsible for toxic shock syndrome. Autoantibodies to V beta segments of T cell receptors have been isolated from patients with rheumatoid arthritis (RA) and systemic lupus erythematosus (SLE). The autoantibodies block TH1-mediated inflammatory autodestructive reactions and are believed to be a method by which the immune system compensates for disease (ref5). T Cell and TCR Diversity Most human T cells express the TCR alpha-beta and either CD4 or CD8 molecule (single positive, SP). A small number of T cells lack both CD4 and CD8 (double negative, DN). Increased percentages of alpha-beta DN T cells have been identified in some autoimmune and immunodeficiency disorders. Gamma-delta T cells are primarily found within the epithelium. They show less TCR diversity and recognize antigens differently than alpha-beta T cells. Subsets of gamma-delta T cells have
Category | Antibody |
Supplier | ThermoFisher |
Application | FC |
Regulatory Status | RUO |
Immunogen | TCR affinity purified from mouse T cell hybridoma DO-11.101 |
Host | Hm |
Clone Number | [H57-597] |
Genebank | TCRB |
Isotype | IgG2 |
Crossreactivity | Ms |
Clonality | Mab |
Format | Liquid; PBS; , with <0.1% sodium azide |
Concentration | 0.5 mg/mL |
Working Dilution | Flow Cytometry (0.3 µg/1x10^6 cells) |
Purity | purified |
Conjugation | Pacific Blue |
Storage Conditions | 4° C, store in dark |
Tech. Data Sheet | View datasheet |
Link To Supplier | https://www.thermofisher.com |
Material Safety Data Sheet | Download PDF |