ITGA2 Monoclonal Antibody (DX5), APC-Cyanine7
Catalog Number | Pack Size | List Price* | Quantity | |
---|---|---|---|---|
A15420 | 100 µg | 574,00 | Add |
* CHF, excl. 8.1% VAT and shipping costs
Product Description
CD49b (Integrin alpha 2, Integrin alpha 2 chain, VLA-2 alpha chain, HM alpha 2) is a member of the integrin family. It is a glycoprotein with molecular weight of 150 kD, and it complexes with CD29 (Integrin beta 1) to form the heterodimeric integrin VLA-2 (integrin alpha 2 beta 1, or GPIa/IIa) complex. VLA-2 is an extracellular receptor for laminin, collagen, and fibronectin, and interaction with its ligands results in the activation of intracellular signaling pathways. It has reported roles in VEGF-induced angiogenesis in vivo, as well as adhesion and lymphocyte activation. CD49b is expressed by NK cells, NK-T cells, monocytes, platelets, and epithelial cells. It is also expressed on adaptive immune cells such as T and B cells, specifically on a subset of CD4+ T cells in the spleen, on intraepithelial and lamina propria lymphocytes in the intestine, as well as on a population of peripheral CD4+ type 1 T regulatory (Tr1) cells that co-express LAG-3.
Category | Antibody |
Supplier | ThermoFisher |
Application | FC |
Regulatory Status | RUO |
Immunogen | RIL-2-propagated NK1.1 cells from C57BL/6 mice. |
Host | Rt |
Clone Number | [DX5] |
Genebank | ITGA2 |
Isotype | IgM,k |
Crossreactivity | Ms |
Clonality | Mab |
Format | Liquid; PBS; , with proprietary stabilizer and <0.1% sodium azide |
Concentration | 0.1 mg/mL |
Working Dilution | Flow Cytometry (0.2 µg/1x10^6 cells) |
Purity | purified |
Conjugation | APC/Cy7 |
Storage Conditions | 4° C, store in dark, DO NOT FREEZE! |
Tech. Data Sheet | View datasheet |
Link To Supplier | https://www.thermofisher.com |
Material Safety Data Sheet | Download PDF |