CD103 Monoclonal Antibody (2E7), Pacific Blue™
Catalog Number | Pack Size | List Price* | Quantity | |
---|---|---|---|---|
A15422 | 100 µg | 432,00 | Add |
* CHF, excl. 8.1% VAT and shipping costs
Product Description
CD103 (ITGAE, Integrin alpha E) is molecule that is expressed on mucosa-associated T lymphocytes and activated cells and on subet of TGF beta -1 cells. In particular, CD103 includes a 150kDa alpha chain and a 120kDa beta chain. CD103 is expressed by 0.5 to 2% of resting lymphocytes in peripheral blood and lymphoid organs. CD103 antibody stains a few bone marrow cells and, rarely, peripheral blood lymphocytes. CD103 is part of the integrin family which are heterodimeric integral membrane proteins composed of an alpha chain and a beta chain. ITGAE encodes an I-domain-containing alpha integrin that undergoes post-translational cleavage in the extracellular domain, yielding disulfide-linked heavy and light chains. In combination with the beta 7 integrin, CD103 protein forms the E-cadherin binding integrin known as the human mucosal lymphocyte-1 antigen. CD103 is preferentially expressed in human intestinal intraepithelial lymphocytes (IEL), and in addition to a role in adhesion, it may serve as an accessory molecule for IEL activation. Diseases associated with CD103 dysfunction include hairy cell leukemia and splenic marginal zone lymphoma.
Category | Antibody |
Supplier | ThermoFisher |
Application | FC |
Regulatory Status | RUO |
Immunogen | Mouse CD103. from C57BL/6J mouse intestinal intraepithelial lymphocytes (IEL) |
Host | Hm |
Clone Number | [2E7] |
Genebank | ITGAE |
Isotype | IgG2 |
Crossreactivity | Ms |
Clonality | Mab |
Format | Liquid; PBS; , with <0.1% sodium azide |
Concentration | 0.5 mg/mL |
Working Dilution | Flow Cytometry (1 µg/1x10^6 cells) |
Purity | purified |
Conjugation | Pacific Blue |
Storage Conditions | 4° C, store in dark |
Tech. Data Sheet | View datasheet |
Link To Supplier | https://www.thermofisher.com |
Material Safety Data Sheet | Download PDF |