c-Kit Monoclonal Antibody (2B8), APC-Cyanine7
| Catalog Number | Pack Size | List Price* | Quantity | |
|---|---|---|---|---|
| A15423 | 100 µg | 430,00 | Add |
* CHF, excl. 8.1% VAT and shipping costs
Product Description
c-Kit, also known as mast/stem cell growth factor receptor (SCFR) or CD117, is a trans membrane type III tyrosine kinase receptor encoded by the c-Kit proto-oncogene, located on chromosome 4 in humans. It is expressed in hematopoietic stem cells, germ cells, mast cells and gastrointestinal tract cajal cells. Upon binding of its ligand stem cell factor (SCF), c-kit dimerizes, resulting in receptor activation and autophosphorylation of various tyrosine residues including tyrosine 703 located on the cytoplasmic domain of the receptor. This modification allows docking of Grb2 and activation of the Ras/ERK signaling pathway. SCF/c-kit can activate multiple downstream signaling pathways including PI3K, PLC-gamma and JAK/STAT. c-kit receptor activation is essential for hematopoiesis, stem cell maintenance and gametogenesis.
| Category | Antibody |
| Supplier | ThermoFisher |
| Application | FC |
| Regulatory Status | RUO |
| Immunogen | IL-3-dependent mast cells derived from normal bone marrow. |
| Host | Rt |
| Clone Number | [2B8] |
| Genebank | KIT |
| Isotype | IgG2b,k |
| Crossreactivity | Ms |
| Clonality | Mab |
| Format | Liquid; PBS; , with proprietary stabilizer and <0.1% sodium azide |
| Concentration | 0.1 mg/mL |
| Working Dilution | Flow Cytometry (0.2 µg/1x10^6 cells) |
| Purity | purified |
| Conjugation | APC/Cy7 |
| Storage Conditions | 4° C, store in dark, DO NOT FREEZE! |
| Tech. Data Sheet | View datasheet |
| Link To Supplier | https://www.thermofisher.com |
| Material Safety Data Sheet | Download PDF |
