CD35 Monoclonal Antibody (E11), FITC


Catalog Number Pack Size List Price* Quantity
A15455 100 µg 404,00 Add

* CHF, excl. 8.1% VAT and shipping costs


Product Description

CD35 (CR1, Complement Receptor 1) is a cell membrane-bound, monomeric glycoprotein and its primary function is to serve as the cellular receptor for C3b and C4b, the most important components of the complement system leading to clearance of foreign macromolecules. CD35 protein mediates cellular binding to particles and immune complexes that have activated complement. The CD35 complex is four different allotypes (C,A,B,D) C is 160 kDa; A is 190 kDa; B is 220 kDa and D is 250 kDa. CD35 is involved in the processing of immune complexes, promoting of binding and phagocytosis of C3b complexes and inhibition of complement activation. CD35 is on neutrophils, eosinophils, monocytes, B-cells, some NK-cells, erythrocytes, myeloid leukemias, follicular dendritic reticulum cells and is negative on basophils. Decreases in expression of CD35 protein and/or mutations in its gene have been associated with gallbladder carcinomas, mesangiocapillary glomerulonephritis, systemic lupus erythematosus and sarcoidosis. Mutations in the CD35 gene have also been associated with a reduction in Plasmodium falciparum rosetting, conferring protection against severe malaria. Alternate allele-specific splice variants encoding different isoforms of CD35 have been characterized. An additional sec

Category Antibody
Supplier ThermoFisher
Application FC
Regulatory Status RUO
Immunogen Human CD35 from Acute monocytic leukemia cells and normal blood monocytes
Host Ms
Clone Number [E11]
Genebank CR1
Isotype IgG1,k
Crossreactivity Baboon, Chimpanzee, Cynomolgus Monkey, Hu, Rhesus Monkey
Clonality Mab
Format Liquid; PBS; , with <0.1% sodium azide
Concentration 0.1 mg/mL
Working Dilution Flow Cytometry (10 µL/1x10^6 cells)
Purity purified
Conjugation FITC
Storage Conditions 4° C, store in dark
Tech. Data Sheet View datasheet
Link To Supplier https://www.thermofisher.com
Material Safety Data Sheet Download PDF