CD14 Monoclonal Antibody (TuK4), Alexa Fluor™ 647
Catalog Number | Pack Size | List Price* | Quantity | |
---|---|---|---|---|
A51013 | 100 Tests | 325,00 | Add |
* CHF, excl. 8.1% VAT and shipping costs
Product Description
CD14 is a 55 kDa GPI-anchored glycoprotein that is constitutively expressed on the surface of mature monocytes, macrophages, and neutrophils. CD14 also serves as a multifunctional lipopolysaccharide receptor, and is released to the serum both as a secreted and enzymatically cleaved GPI-anchored form. CD14 binds lipopolysaccharide molecule in a reaction catalyzed by lipopolysaccharide-binding protein (LBP), an acute phase serum protein. The soluble sCD14 can discriminate slight structural differences between lipopolysaccharides and is important for neutralization of serum allochthonous lipopolysaccharides by reconstituted lipoprotein particles. Further, CD14 has been shown to bind apoptotic cells, and can affect allergic, inflammatory and infectious processes. Alternative splicing results in multiple transcript variants encoding the same CD14 isoform. Diseases associated with CD14 dysfunction include mycobacterium chelonae infection and Croup.
Category | Antibody |
Supplier | ThermoFisher |
Application | FC |
Regulatory Status | RUO |
Immunogen | Human CD14 |
Host | Ms |
Clone Number | [TuK4] |
Genebank | CD14 |
Isotype | IgG2a |
Crossreactivity | Hu |
Clonality | Mab |
Format | Liquid; PBS; pH 7.4, with 1% BSA and 0.0325% sodium azide |
Concentration | 0.04 mg/mL |
Working Dilution | Flow Cytometry (5 µL/1x10^6 cells) |
Purity | Affinity chromatography |
Conjugation | Alexa Fluor 647 |
Storage Conditions | 4° C, store in dark |
Tech. Data Sheet | View datasheet |
Link To Supplier | https://www.thermofisher.com |
Material Safety Data Sheet | Download PDF |