IL-8 (CXCL8) Polyclonal Antibody
Catalog Number | Pack Size | List Price* | Quantity | |
---|---|---|---|---|
AHC0881 | 100 µg | 598,00 | Add |
* CHF, excl. 8.1% VAT and shipping costs
Product Description
Centrifuge vial prior to opening. Reconstitute in sterile water to 0.1-1.0 mg/mL. Interleukin 8 (IL-8, CXCL8) is a 72 amino acid pro-inflammatory factor which belongs to the CXC subfamily of chemokines, and are bound by the cell surface receptors IL-8RA and IL-8RB. IL-8 functions as a chemoattractant and potent angiogenic factor. The expression and secretion of IL-8 can be induced by diverse inflammatory stimuli in many cells, including macrophages and endothelial cells. In endothelial cells, IL-8 is present in storage vesicles called Weibel-Palade bodies. IL-8, first isolated from osteosarcoma cells, contains the ELR-motif (N-terminal Glu-Leu-Arg amino acid sequence) and signals through the CXCR1 and CXCR2 receptors. Previous nomenclature for IL-8 includes neutrophil activating protein 1 (NAP-1), granulocyte chemotactic protein 1 (GCP-1), monocyte-derived neutrophil-activating peptide (MONAP) and protein 3-10C. IL-8 and ten other members of the CXC chemokine gene family form a chemokine gene cluster in a region mapped to chromosome 4q. Cancer studies have demonstrated a role for IL-8 in the angiogenesis and growth of tumours, and IL-8 is believed to play a role in the pathogenesis of bronchiolitis, a common respiratory tract disease caused by viral infection.
Category | Antibody |
Supplier | ThermoFisher |
Application | EL, IHC, N, WB |
Regulatory Status | RUO |
Immunogen | Highly purified (>98% pure) recombinant human endothelial IL-8 (77 amino acid residues). |
Host | Rb |
Genebank | CXCL8 |
Isotype | IgG |
Crossreactivity | Hu |
Clonality | Pab |
Format | Lyophilized; PBS; pH 7.2, with no preservative |
Working Dilution | Western Blot (1:1,000), Neutralization (Assay-dependent), Immunohistochemistry (Assay-dependent),... |
Purity | purified |
Conjugation | Unconjugated |
Storage Conditions | -20°C |
Tech. Data Sheet | View datasheet |
Link To Supplier | https://www.thermofisher.com |
Material Safety Data Sheet | Download PDF |