GRB2 Monoclonal Antibody (2GB04 (C1.4))
| Catalog Number | Pack Size | List Price* | Quantity | |
|---|---|---|---|---|
| AHO0522 | 500 µL | 453,00 | Add |
* CHF, excl. 8.1% VAT and shipping costs
Product Description
This antibody reacts with an epitope at aa 54-62. Staining of formalin-fixed paraffin-embedded tissues requires boiling tissue sections in 10mM citrate buffer, pH 6.0, for 20 min followed by cooling at room temperature for 20 min. Recommended positive controls include HeLa cells and tonsil tissue. GRB 2 protein contains one SH2 domain flanked on both sides by an SH3 domain. In response to EGF, GRB 2 binds, through its SH3 domains, to the guanine nucleotide exchange factor, Sos. The GRB 2-Sos complex then binds the EGF receptor. These interactions play a critical role in the activation of the p21 ras signaling pathway.
| Category | Antibody |
| Supplier | ThermoFisher |
| Application | IHC |
| Regulatory Status | RUO |
| Immunogen | Purified recombinant human Grb2 protein. |
| Host | Ms |
| Clone Number | [2GB04 (C1.4)] |
| Genebank | GRB2 |
| Isotype | IgG1,k |
| Crossreactivity | Bo, Hu, Ms, Rt, Xenopus |
| Clonality | Mab |
| Format | Liquid; PBS; pH 7.4, with 0.2% BSA and 0.09% sodium azide |
| Concentration | 0.2 mg/mL |
| Working Dilution | Immunohistochemistry (Paraffin) (Assay-Dependent) |
| Purity | Protein G |
| Conjugation | Unconjugated |
| Storage Conditions | 4° C |
| Tech. Data Sheet | View datasheet |
| Link To Supplier | https://www.thermofisher.com |
| Material Safety Data Sheet | Download PDF |
